ACE and antiphospholipid syndrome: Other important measures included therapy with an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II (ATII) receptor antagonist in cases of arterial hypertension and/or proteinuria, followed by gonadotropin releasing hormone (GnRH) analogs or fertility preservation, prior to therapy with CP, prescription of progestogen (especially in antiphospholipid syndrome), vitamin D substitution and the implementation of vaccinations and infection prophylaxes.