In addition to the CP dose limitation that appears to minimize the risk of fertility reduction (57), the combined use of GnRH analogs with CP therapy was shown to be associated with a significant reduction of POF among premenopausal women with SLE, suggesting that the addition of GnRH analog can be a strategy to prevent POF among premenopausal women (58). This evidence concerns the gene GNRH1 and systemic lupus erythematosus.