Otani et al. previously reported that CCL2/CCR2 blockade alleviates photoreceptor cell death in RP mice (24), and here we expand this finding by showing that depletion of Ccl2 in rd10 mice decreases IMo/mφ recruitment into the retina, preserves cone cells, suppresses neuroinflammatory molecules involved in myeloid cell activation (Snca and Tcirg1), induction of inflammatory gene expression (Nfkb1 and Egr1), and promotion of cell death/inflammation (Bnip3). Here, CCR2 is linked to retinitis pigmentosa 1.