STAT2 and infection: At 3 days postinfection (dpi), no virus could be detected in either the serum nor in any of the tissues sampled (Supplementary Material Appendix, Figure S1), leading us to hypothesize that SFTSV is either unable to infect these animals or cannot sufficiently evade the murine innate immune response, and hence establish an infection, even in the presence of human STAT2.