The HNRNPA2B1 levels were positively associated with TAR DNA binding protein (TARDBP) (R = 0.82), DExH-Box Helicase 9 (DHX9) (R = 0.8), heterogeneous nuclear ribonucleoprotein R (HNRNPR) (R = 0.8), serine and arginine-rich splicing factor 1 (SRSF1) (R = 0.79), heterogeneous nuclear ribonucleoprotein D (HNRNPD) (R = 0.77), and heterogeneous nuclear ribonucleoprotein M (HNRNPM) (R = 0.76) genes (all P < 0.001) in pan-cancer. Here, HNRNPA2B1 is linked to cancer.