To prove our hypothesis, we studied the role of hsa_circ_0003570, hsa-miR-138-5p, and RGS5 in the malignant biological behavior of IH in the hemangioma endothelial cells (HEMEC) model, and through our research results, we provided a new direction for the treatment of IH. This evidence concerns the gene RGS5 and isolated hemihyperplasia.