In recent years, more than a dozen of different drugs have been tested clinically and have not shown positive results or efficacy.98 Benzofurans and terpenoids as inhibitors of butyryl cholinesterase (BuChE), acetylcholinesterase (AChE), gamma secretase, β-secretase, tau misfolding and β-amyloid (Aβ) aggregation, have good effects in the treatment of AD.99 Here, ACHE is linked to Alzheimer disease.