In line with this, Gao et al. [24] revealed that ferulic acid, which is a derivative of hydroxycinnamic acid, can trigger HeLa cells to lead to cell cycle arrest; this is indicated by decreased expression of cyclin-D1 and p53 and p21 proteins, where cyclin-D1 expression is controlled by c-Myc protein and p53 and p21 are controlled by MDM2. A study conducted by Chen et al. [25]showed that the derivative component of hydroxycinnamic acid can inhibit histone deacetylase and inosine monophosphate which makes cancer cells enter cell cycle arrest and leads to apoptosis. This evidence concerns the gene MDM2 and cancer.