By comparing ANGPTL8 levels among non-pregnant women, pregnant women with normal glucose tolerance (NGT) and GDM women, Huang et al. revealed significantly elevated ANGPTL8 levels in NGT pregnant women compared to non-pregnant women but no statistical difference was found between circulating ANGPTL8 levels in GDM pregnant women and normal pregnant women [11]. This evidence concerns the gene ANGPTL8 and gestational diabetes.