Dysfunction of metabolic parameters (TG, TC, insulin, HOMA-IR, FPG, OGTT, and glucose AUC) indicated remarkably increased metabolic burden in GDM patients, which coincides with relatively decreased circulating ANGPTL8 levels, suggesting that circulating ANGPTL8 is associated with the development of GDM. This evidence concerns the gene ANGPTL8 and gestational diabetes.