Furthermore, the analysis showed that certain RNAs such as HUWE1, hsa-miR-6780b-5p, has_circ_0058208 and lnc-G3BP1-3:8 were found to be in central positions of the network, suggesting their importance in promoting pancreatic cancer progression on many levels.18 This evidence concerns the gene G3BP1 and familial pancreatic carcinoma.