Our finding, that low levels of IGF-I relate to QTc prolongation and therefore higher sudden cardiac death risk, fits with several other known adverse cardiovascular effects of IGF-I deficiency, that include accelerated cardiovascular aging, reduced cardiac contractility, hypertrophy, hypertension, coronary disease and even atrial fibrillation (19, 53, 70). Here, IGF1 is linked to hypertrophy.