In imputed models, observed associations between IGF-I/IGFBP-3 molar ratio at 60–64y and ΔIGF-I/IGFBP-3 ratio with QTc, were only slightly attenuated after removing the 273 participants with known cardiovascular disease (respectively: β −17.60 ms/unit [−34.41, −0.80], p = 0.040 and β −2.35 ms/unit/10 years [−4.44, −0.24], p = 0.029, Supplementary Table 3). This evidence concerns the gene IGF1 and cardiovascular disorder.