Another FKBP5 SNP, rs1360780, also showed a trend for a genotype by time interaction with depression severity of the patients (P ​= ​0.075), where the increase in depression severity over time among the homozygous wild type patients was reported to be smaller, compared to those having at least one copy of the rare allele. The gene discussed is FKBP5; the disease is major depressive disorder.