Detection results of Western blot revealed that levels of HIF-1α and VEGF mRNA in the bone marrow microenvironment of CML patients were elevated compared with those of relatively normal patients, indicating that HIF-1α and the downstream target gene VEGF were of vital significance in the hypoxic bone marrow microenvironment. This evidence concerns the gene HIF1A and chronic myelogenous leukemia, BCR-ABL1 positive.