In this study, we analyzed GSE75010 datasets and identified 20 DEGs between preeclampsia samples and normal samples, including FLT1, FSTL3, COL17A1, SASH1, HTRA4, SH3BP5, LEP, DIO2, BHLHE40, FAM26D, TMEM45A, NPNT, INHA, HK2, SERPINA3, SPX, UCA1, TREM1, CRH, and CP. This evidence concerns the gene HK2 and preeclampsia.