In this study, we used SVM-RFE and LASSO logistic regressive methods to screen the possible biomarkers in preeclampsia and identified nine abnormally expressed genes, including FLT1, FSTL3, COL17A1, DIO2, BHLHE40, FAM26D, NPNT, SERPINA3, and SPX. This evidence concerns the gene SERPINA3 and preeclampsia.