In this study, we analyzed GSE75010 datasets and identified 20 DEGs between preeclampsia samples and normal samples, including FLT1, FSTL3, COL17A1, SASH1, HTRA4, SH3BP5, LEP, DIO2, BHLHE40, FAM26D, TMEM45A, NPNT, INHA, HK2, SERPINA3, SPX, UCA1, TREM1, CRH, and CP. The gene discussed is SERPINA3; the disease is preeclampsia.