In this study, we used SVM-RFE and LASSO logistic regressive methods to screen the possible biomarkers in preeclampsia and identified nine abnormally expressed genes, including FLT1, FSTL3, COL17A1, DIO2, BHLHE40, FAM26D, NPNT, SERPINA3, and SPX. Here, CALHM4 is linked to preeclampsia.