In this study, we used SVM-RFE and LASSO logistic regressive methods to screen the possible biomarkers in preeclampsia and identified nine abnormally expressed genes, including FLT1, FSTL3, COL17A1, DIO2, BHLHE40, FAM26D, NPNT, SERPINA3, and SPX. The gene discussed is BHLHE40; the disease is preeclampsia.