Group II (DMBA) showed significantly increased expression of VEGFR2 in endothelial cells (membrane) and tumor cells (nuclei, cytoplasm, and membranes) while, pAKT1 expression was observed only in tumor cells (cell membrane and nucleus) when compared to group I. The treated group III (DMBA + monacolin X) and group IV (SU5416) showed decreased expression levels of these proteins, suggesting the potent antiangiogenic activity of monacolin X in DMBA induced mammary carcinogenesis. Here, KDR is linked to neoplasm.