VEGFR2 is the main signal transducer responsible for angiogenesis because it has strong intrinsic kinase activity and plays a decisive role in the regulation of tumor angiogenesis.64 Phosphorylation of VEGFR2 is most important to regulates downstream signaling65,66 in turn activating Akt which helps in cell survival, p38 mitogen-activated protein kinase (p38 MAPKAP) help in actin reorganization and vascular permeability, FAK helps in cell migration and ERK1/2 in cell proliferation. Here, MAPK3 is linked to neoplasm.