Our results are in line with other studies where the antitumor effect of in vivo previously reported.55,70 In addition, the pVEGFR2 and pAkt levels were reduced in the monacolin X and SU5416 treated group in compared to that of DMBA breast cancer induced group suggesting the monacolin X is able to decrease the tumor angiogenesis process and kill both cancer cells and endothelial cells thus monacolin X could be a potent antiangiogenic VEGFR2 inhibitor. Here, KDR is linked to breast cancer.