As for the regulated targets in the renal cell carcinoma pathway, TGFB1 (Song et al., 2018), EPAS1 (Cho et al., 2016), HIF1A (Shen et al., 2011), VEGFA (Sun et al., 2020), KRAS, and PIK3CA (Lee et al., 2020) regulated by miR-140 have been reported to interfere with KIRC. The gene discussed is PIK3CA; the disease is hereditary clear cell renal cell carcinoma.