m6A regulators that modulate m6A modification, including “writers” (methyltransferases), “readers” (binding proteins), and “erasers” (demethylases), potentially participate in cancer growth, invasion and metastasis, and immunomodulatory abnormalities in multiple types of cancers, including ccRCC (He et al., 2019; Gu et al., 2021; Uddin et al., 2021). Here, MBD2 is linked to cancer.