Because ischemia/reperfusion-induced, sepsis-associated, and drug-induced AKI, as well as diabetes-associated CKD, are common manifestations of kidney disease that are usually associated with poor prognosis, and the potential protective effects of Nrf2 for these diseases have been thoroughly investigated in preclinical studies or clinical trials, we focus on these specific types of kidney injury. This evidence concerns the gene NFE2L2 and acute kidney injury.