The expression of NR_033515 in the kidney, peripheral blood, urine, and serum is increased compared with the control group [19, 28], which is related to renal fibrosis, and enhance expression levels of fibrogenesis-related gene proteins (P38, ASK1, and ASK1), fibronectin and α-SMA [19]. Here, MAP3K5 is linked to renal fibrosis.