PCDH19 and systemic sclerosis: Notably, leading clinical features of PCDH19-CE people point to early onset of seizures accompanied by fever episodes as one of the characteristics of the condition.6,18,57 Thus, the results on the SSc obtained here complement (with a more disease-relevant seizure induction protocol) previous results on increased susceptibility to seizures in rats electroporated with Pcdh19 shRNA in the hippocampus by injection with the γ-aminobutyric acid type A (GABAA) receptor antagonist pentylenetetrazol (PTZ)36 or in female Pcdh19+/− and Pcdh19–/– mice by flurothyl injection or 6-Hz psychomotor test.24