PCDH19 and Cognitive impairment: PCDH19-CE is an infantile-onset epilepsy syndrome also characterized by psychiatric (including autism-related), sensory, and cognitive impairments of varying degrees.1,2,3,4,5,6 PCDH19 is part of a large family of cell-adhesion molecules that play specific roles in the patterning and wiring of diverse brain areas during development.