A large number (32%) of people with PCDH19-CE also carry a diagnosis of ASD39,48 with social deficits early in life that persist and may become more prominent in adulthood.1 Here, in animals transfected with Pcdh19 shRNA in the SSc, we found impaired social behaviours in terms of decreased vocalization and huddling behaviour in young pups and poor sociability in adult animals. This evidence concerns the gene PCDH19 and systemic sclerosis.