PCDH19 and systemic sclerosis: Formal diagnosis of ASD in people with PCDH19-CE also includes aberrant sensory perception, with both hypo- or hypersensitivity to pain reported as a comorbidity.39,47,48 Here, we found that pups with PCDH19 downregulation in the SSc showed faster paw withdrawal (thus, hypersensitivity) than their control littermates in the hot plate test.