Other studies have shown that after viral infection, IFITM3 is induced by type I interferon and promotes the degradation of IFN regulatory factor 3 (IRF3) by enhancing IRF3 autophagy and migration to autophagosome, thus negatively regulating the RIG-I-like receptor- (RLR-) mediated signaling pathway of type I interferon production [57]. This evidence concerns the gene DHX58 and viral infectious disease.