PPIG and chronic cystitis: In this study, we examine the effect of imatinib administration using a prevention design, via oral gavage, or treatment design, via intravesical bladder infusion, on urinary inflammatory mediators and cell signaling kinases in an acute (4 h) CYP-induced cystitis female mouse model, using real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assays (ELISAs), and immunohistochemistry (IHC).