BDNF urinary bladder protein expression was significantly (p ≤ 0.05) increased in mice with 4 h CYP-induced cystitis that received saline or imatinib (1.7-fold each) intrabladder infusion, compared to imatinib infused controls (no CYP), but was not significantly different from vehicle (saline) infused controls (Figure 5E). This evidence concerns the gene BDNF and cystitis.