In rodent models of CYP-induced cystitis, functional and pharmacological studies suggest pERK and pAKT may induce pCREB, mTOR, type 1 collagen, and cytokine expression, including IL-6 (Kay et al., 2013; Qiao et al., 2014; Sun et al., 2015). Here, EIF2AK3 is linked to chronic cystitis.