PPIG and chronic cystitis: Functional improvements with imatinib administration in models of urinary bladder dysfunction, including acute (4 h) CYP-induced cystitis (Perkins et al., 2022; Kubota et al., 2004, 2006; Biers et al., 2006; Abrams et al., 2012; Deng et al., 2013; Kjell et al., 2015; Preis et al., 2015; Sancho et al., 2017; Giglio et al., 2018), may be mediated by multiple factors including changes in the urinary bladder inflammatory milieu and/or cell signaling pathways.