RSUME and PTTG are both upregulated in human pituitary adenomas (9, 36), and this positive correlation of expressions involves not only an increment of PTTG protein in pituitary tumor cells, but also an improved half-life of PTTG protein and a co-regulation with estrogens of the PTTG induction. This evidence concerns the gene PTTG1 and pituitary gland adenoma.