In this study, a two-sample MR method utilizing GWAS summary-level data was applied to explore the causal association of T2DM and glycemic traits (FG, FI, and HbA1c) with a wide range of CVDs as well as lipid traits [HDL-C, LDL-C, triglycerides, apoA, apoB, and Lp(a)]. Here, APOB is linked to type 2 diabetes mellitus.