We also found T2DM was causally related to lower levels of HDL-C (OR = 0.965, 95% CI: 0.958-0.973, p = 2.13 × 10-18) and apoA (OR = 0.982, 95% CI: 0.977-0.987, p = 1.63 × 10-11) but a higher level of triglycerides (OR = 1.060, 95% CI: 1.036-1.084, p = 6.76 × 10-7) (Figure 3). The gene discussed is LPA; the disease is type 2 diabetes mellitus.