Genetically predicted FI was suggested to be positively corelated with PAD (OR = 2.804, 95% CI: 1.604-4.902, p = 2.97 × 10-4), IHD (OR = 2.020, 95% CI: 1.374-2.972, p = 3.53 × 10-4), MI (OR = 2.009, 95% CI: 1.317-3.064, p = 1.20 × 10-3) and HT (OR = 1.098, 95% CI: 1.054-1.144, p = 8.31 × 10-6) but negatively associated with HDL-C (OR = 0.644, 95% CI: 0.549-0.755, p = 6.56 × 10-8) and apoA (OR = 0.790, 95% CI: 0.713-0.874, p = 5.37 × 10-6). The gene discussed is LPA; the disease is peripheral arterial disease.