Subjects with FGF-21 levels of ≥1.40 pg/dl had greater portion of hypertension, albuminuria, or advanced CKD but the uses of RAS blockade were also more common comparing with those with FGF-21 < 1.40 pg/dl (56% vs 41%, p = 0.009) (Table 3). This evidence concerns the gene FGF21 and Hypertension.