FGF21 and chronic kidney disease: Furthermore, the specific cut-off level of FGF-21 (higher than 1.40 pg/dl) also exhibited excellent predictions of the renal outcomes and this association was similar with primary cohort across all major subgroups stratified by the factors that were biologically or statistically relevant to the risks of renal composite events, including age, gender, blood pressure, the status of albuminuria or CKD, and use of blockades of RAS or not.