demonstrated that FGF-21 is one of the 14 biomarkers in addition to the traditional factors, such as age, HbA1C, eGFR, or albuminuria at baseline, that improve the prediction of rapid CKD progression by the design of the case–control study in subjects with T2DM as well as advanced CKD (20). The gene discussed is FGF21; the disease is type 2 diabetes mellitus.