CRTC2 and Insulin resistance: In the same line, and in an independent study, it was also described that OGT overexpression promoted insulin resistance (54), and that hyperglycemia promotes the O-GlcNAcylation of CREB-regulated transcription coactivator 2 (CRTC2), which induces the transcription of gluconeogenic genes, contributing to increase hepatic glucose production in diabetic animal models.