One potential mechanism that can explain this latter phenomenon is an increase in protein levels of OGT, which may induce the intracellular O-GlcNAcylation upregulation in spite of the limited availability of free UDP-GlcNAc (29–31) We will examine the effect of O-GlcNAcylation in the main organs and tissues involved in glucose metabolism and its effect on glucose homeostasis and type 2 diabetes development. This evidence concerns the gene OGT and type 2 diabetes mellitus.