CRP and delirium: Another study also found that microstructural changes in white matter were closely associated with systemic inflammatory responses and concluded that in patients with COVID-19 encephalopathy, the average apparent diffusion coefficient (ADC) in the white matter region of the genu of the corpus callosum, ATR, and EC was increased with local CRP levels, consistent with the delirium associated with the frontal-subcortical syndrome (Rhally et al., 2021).