Therefore, through ACE2/Ang-(1–7)/mas signaling pathway, the release of brain-derived neurotrophic factor (BDNF) is inhibited, which interferes with glial cells and peripheral cells of neuronal cells and induces the occurrence of mental diseases such as depression, anxiety, and cognitive impairment (Zheng et al., 2014; Kumar et al., 2020). The gene discussed is BDNF; the disease is major depressive disorder.