In this regard, selective expression of leptin receptors in hypothalamic POMC neurons has been shown to prevent diabetes in leptin receptor-deficient db/db mice, independent of changes in food intake and body weight (Coppari et al., 2005; Huo et al., 2009; Fujikawa et al., 2010; Berglund et al., 2012). This evidence concerns the gene LEPR and diabetes mellitus.