Both sAPPα and sAPPβ are fragments of the Alzheimer’s disease‐linked amyloid precursor protein (APP; Fig EV1E and F) that are generated by the proteolytic activity of ADAM10 or ADAM17 (sAPPα) or by BACE1 (sAPPβ; Buxbaum et al, 1998; Lammich et al, 1999; Jorissen et al, 2010; Kuhn et al, 2010). This evidence concerns the gene APP and glycogen storage disease VI.