We conclude that different proteases, including TMPRSS2, ADAM10, ADAM17, and potentially others, may prime S2 and, thus, facilitate: (i) infection through the fusion of the SARS‐CoV‐2 virus with host cells, or (ii) syncytia formation of S‐expressing SARS‐CoV‐2‐infected cells with host cells. Here, TMPRSS2 is linked to infection.