But these 77 tumors that did not classify with known tumors formed 4 distinct clusters, now known as CNS neuroblastoma with FOXR2 activation, CNS Ewing sarcoma family tumor with CIC alteration, CNS high-grade neuroepithelial tumor with MN1 alteration, and CNS high-grade neuroepithelial tumor with BCOR alteration, all driven by specific gene fusions [25]. This evidence concerns the gene FOXR2 and neuroepithelial neoplasm.