IDH2 and neoplasm: As shown in Figure 6D, we found that both EGFR TKI and IDH inhibitor suppressed the growth of HCC827 cells and that the combination of an EGFR TKI and IDH inhibitor suppressed its growth to a lower level, indicating that the combination of an IDH inhibitor and EGFR TKI is more efficient in inhibiting tumor cell growth than the single treatment.