In our study, it was found that there were more IDH mutation isoforms (amino acid substitution at arginine residue) in NSCLC, including IDH1R132C, IDH1R132H, IDH1R132L, IDH1R132G, IDH1R132S, IDH1R100Q, IDH2R140Q, IDH2R140W, IDH2R140L, IDH2R172S, and IDH2R172M. The gene discussed is IDH1; the disease is non-small cell lung carcinoma.