CRP and rheumatoid arthritis: Similarly, when focusing on RA patients, 1-month supplementation significantly decreased only VAS activity (1 to 2 studies, including 46 to 82 patients), whereas 3-month supplementation significantly decreased all clinical parameters and no biological parameters (ESR, CRP level) (3 to 14 studies, including 204 to 669 patients) (Additional file 5, Fig. 2).