APOE and Alzheimer disease: As we confirm herein with multivariable modeling, the stressors summated by HIV disease duration and other traditional AD risk factors (age and APOE \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upvarepsilon$$\end{document}ε4), but not the extent of microgliosis, appear relevant to initiation of amyloid deposits [22].