In our study, we showed that PA2G4 enhanced the migration and invasion ability of cancer cells, induced a rearrangement of F-actin and modulated the expression of EMT-related molecular markers (E-cadherin, N-cadherin, occluding, Vimentin, α-SMA and ZO-1) as well as TFs (ZEB1, ZEB2 and Snail). Here, ZEB1 is linked to cancer.