We proved that LncRNA-PACERR promotes malignant progression of pancreatic cancer through two pathways: as ceRNA sponging miR-671-3p to activate the KLF12/AKT/c-myc pathway and interacting with IGF2BP2 to enhance KLF12 and c-myc stability. Here, KLF12 is linked to familial pancreatic carcinoma.