In this study, we provided the expression levels of LncRNA-PACERR in TAMs in human pancreatic cancer, validated the pro-oncogenic functions of LncRNA-PACERR through biological experiments and revealed that LncRNA-PACERR sponges miR-671-3p to activate the KLF12/AKT/c-myc pathway and interacts with IGF2BP2 to enhance the stability of KLF12 and c-myc. Here, KLF12 is linked to pancreatic neoplasm.