For metastasis mouse models, we observed that these mice had similar prognosis as the mice in the subcutaneous tumour model and the number of metastatic cells in liver was diminished and the number of CD163+ cells and CD206+ cells in metastatic foci (number of CD163 + /CD206 + cells per field) was decreased after knockdown of LncRNA-PACERR in TAMs (Fig. 3f–h). The gene discussed is MRC1; the disease is neoplasm.