Recently, we have reported several enzymes, such as fructose-1,6-biphosphatase (FBP1), urine diphosphate-galactose ceramide galactosyltransferase (UGT8) and phospholipid scramblase 1 (PLSCR1), were tightly correlated with breast cancer aggressiveness [20–22]. This evidence concerns the gene PLSCR1 and breast cancer.