FBN1 and androgen insensitivity syndrome: Rare variants in FBN1 were first identified in severe AIS North American patients with European ancestry (n = 344), other ancestral backgrounds (n = 47) and replicated in an independent cohort of Han Chinese (n = 370), suggesting that this variant can be predictive of curve severity and promising as a new option for early diagnosis and more timely treatment of severe AIS [9].