AML with t(8;21)(q22;q22);RUNX1/RUNX1T1 and inv(16)/t(16;16);CBFB/MYH11 gene rearrangement, which is called core-binding factor AML (CBF-AML), makes fusion oncoprotein, which leads to transcriptional deregulation and impaired hematopoietic cell differentiation. Here, RUNX1T1 is linked to acute myeloid leukemia.