The recent technological advances led us to identify several mutations of the epigenetically relevant genes, including IDH1/2, Tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3A (DNMT3A), and additional sex combs-like (ASXL)1, all of which are associated with the pathogenesis of AML [128–130]. Here, ASXL1 is linked to acute myeloid leukemia.