Another autophagy inhibitor, SAR405, is a highly potent small-molecule inhibitor of phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3)/Vps34 and blocks autophagy to reduce AML cell proliferation and the repopulating capacity of FLT3-ITD AML cells [93, 199]. The gene discussed is PIK3C3; the disease is acute myeloid leukemia.