NPM1 and acute myeloid leukemia: The genetic alterations of AML are complicated and generally categorized into nine groups: signaling molecules (59%), DNA methylation (44%), chromatin modification (30%), nucleophosmin (NPM1) (27%), myeloid transcription factor (22%), transcription factor fusion (18%), tumor suppressor (16%), spliceosome complex (14%) and cohesion complex (13%) [25].