Due to III: 1 with early ECG abnormality and II: 5 proband with ARVC/D and complex complications carrying LMNA p.A242V and LMNA p.A242V/LAMA4 p.A225P (Fig. 1 and Table 5), respectively, we speculate that the patients of I: 1 and II: 1 who died of RVHF and cerebral thromboembolism also carry LMNA p.A242V. Here, LAMA4 is linked to Arrhythmogenic right ventricular dysplasia.