The value of support score (SS)/classification score (CS) of joint pathogenicity reached 100.00/0.95 (99% zone candidate disease-causing) for LMNA p.A242V/LAMA4 p.A225P, 100.00/0.88 (99% zone candidate disease-causing) for LAMA4 p.A225P/RYR2 p.T858M and 98.60/0.75 (95% zone candidate disease-causing) for LMNA p.A242V/RYR2 p.T858M, which indicates that there are the high risks of joint pathogenicity for cardiomyopathy among these three variants. The gene discussed is LMNA; the disease is cardiomyopathy.