Due to a lack of blood DNA samples and detailed clinical information on I: 1, II: 1 and II: 2 before death, we can’t evaluate the influence of RYR2 p.T858M on the risk of ARVC/D, thromboembolism, ECG abnormality and sudden death. This evidence concerns the gene RYR2 and arrhythmogenic right ventricular cardiomyopathy.