Our study first illustrated that LMNA p.A242V might participate in the pathogenesis of familial ARVC/D with RVHF and cerebral thromboembolism, while LAMA4 p.A225P may be associated with ARVC/D and hereditary ECG abnormality. This evidence concerns the gene LMNA and arrhythmogenic right ventricular cardiomyopathy.