RYR2 and Arrhythmogenic right ventricular dysplasia: c.5654G > A, p.G1885E and c.5656G > A, p.G1886S) of RYR2 were reported to change the subunit composition and alter the behavior of the tetramer channel complex of the RYR2 channel, which therefore causes sarcoplasmic reticulum-Ca2+ depletion and induces ARVC/D and HF [56].