The II: 3 with ARVC/D carry LAMA4 p.A225P (negative of LMNA p.A242V and RYR2 p.T858M), while the II: 4 and III: 6 with hereditary ECG abnormality carry LAMA4 p.A225P/RYR2 p.T858M, both of which inherited from I: 2, suggesting that LAMA4 p.A225P may be a pathogenic etiology of ARVC/D and hereditary ECG abnormality. The gene discussed is LAMA4; the disease is arrhythmogenic right ventricular cardiomyopathy.