The results showed that II: 5 carried 38 variants associated with cardiomyopathy and arrhythmia, including LMNA, ACTA1, RYR2, MYL2, MYH7, TPM1, TTN, MYOZ2, PDLIM3, LAMA4 and KIAA0196. As demonstrated in Sanger sequencing, II: 5 carried with four variants of LMNA p.A242V (NM_001257374, c.C389T), LAMA4 p.A225P (NM_001282626, c.C725T), RYR2 p.T858M (NM_001035, c.C2573T) and KIAA0196 p.H852R (NM_014846, c.A2555G). The gene discussed is RYR2; the disease is cardiac arrhythmia.