According to our previous study, RYR2 mutation is common in cardiac diseases, such as catecholaminergic polymorphic ventricular tachycardia, atrial fibrillation and ARVC/D, which may cause life-threatening ventricular arrhythmias and unexplained sudden death [21]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.