Interestingly, risk genes with high homeostatic expression in microglia (Apoe, Trem2, Cd33, and Ms4a4a) were positively regulated by BIN1, whereas neuronal AD risk genes (Cnn2 and Gria1) and autophagy genes (Sqstm1) were negatively regulated by BIN1. This evidence concerns the gene CD33 and Alzheimer disease.