To test our hypothesis, we transfected AS-tDR-007333 and its inhibitor into NSCLC cells and found that overexpression of AS-tDR-007333 increased the expression levels of HSPB1 gene and protein, whereas knockdown of AS-tDR-007333 decreased HSPB1 expressions (Fig. 6A–D). This evidence concerns the gene HSPB1 and non-small cell lung carcinoma.