In vitro experiments suggest that this secondary pyroptosis is mediated by Gasdermin-E, instead of Gasdermin-D [328]; Brie and colleagues found casp-1 and cleaved Gasdermin-D mediated pyroptosis of oligodendrocytes and microglia in the EAE model and within brain lesions of people with MS [329]. Here, GSDMD is linked to myeloid sarcoma.