Despite the downstream activation of Drp1 by RIPK1/RIPK3/MLKL, necroptosis does not require activation of Drp1 [313–315], suggesting that Drp1-mediated mitochondrial deficiency is a byproduct, and not a direct cause, of necroptosis. The gene discussed is DNM1L; the disease is hyperinsulinemic hypoglycemia, familial, 4.