CXCL8 and Thrombocytopenia: In contrast, PedSep-D had the most profound inflammatory response with highest M-CSF, IL-8, SCF, sCD163, IL-16, IL-10, TNF, and MIP1α levels, and thrombotic microangiopathic response with lowest ADAMTS13 activity decreased to < 57% of control with thrombocytopenia.