TRPM8 and Hepatic fibrosis: In general, despite the lack of more in-depth investigation, these data lay the basic groundwork for hypothesizing that hepatic fibrosis alleviation might be achievable through an alternative route, that is TRPM8 blockage may lead to less pro-inflammatory cytokines secretion, which suppresses the activation of cholangiocytes and, thus, improves liver fibrosis.