PTGS2 and viral infectious disease: It has been determined previously that the overexpression of Prostaglandin E2/ Cyclooxygenase 2 (PGE2/COX-2) leads to pathogenesis in several bacterial, fungal, and viral infections, such as Escherichia coli [74, 75], Streptococcus suis [76], Chlamydia trachomatis [77], Candida albicans [78].