For the first time, it was found that ACP cystic fluid affects the expression of the Npy, Fgfr2, Rnpc3, Sst, and Pcsk1n genes and the cellular interaction of Agrp–Mc3r in hypothalamic neurons and can trigger inflammatory activation of microglia to damage the hypothalamus, which may be related to the upregulation of the CD74–APP interaction and deposition of β-amyloid, implying that there may be a similar mechanism between ACP cystic fluid damage to the hypothalamus and neurodegenerative diseases. The gene discussed is MC3R; the disease is neurodegenerative disease.