Interestingly, we also found that in addition to the upregulated expression of genes related to microglial inflammatory activation (H-2 gene), genes related to neurodegenerative diseases, such as CD74 and APOE [52, 53], were also upregulated in the hypothalamus of mice in the cystic fluid group (Fig. 4E). Here, CD74 is linked to neurodegenerative disease.