After the detection of 3 HMGB2-derived circRNAs in 8 pairs of NSCLC tissues and matched normal tissues, circHMGB2 (hsa_circ_0071452) was found to be highly expressed in tumor tissues, and high circHMGB2 expression was identified as an indicator of poor prognosis in NSCLC patients. This evidence concerns the gene HMGB2 and neoplasm.