To further verify the role of circHMGB2 in regulating the type 1 IFN response, the phosphorylation of STAT1, the expression of CARM1 and the expression of the IFN response genes ISG15 and IFIT were evaluated in tumor tissues from 120 NSCLC patients using IHC. Here, IFNA1 is linked to non-small cell lung carcinoma.