Mechanistically, HMGB2 sponged miR-181a-5p and further blocked the inhibition of the downstream molecule CARM1, which is responsible for the inactivation of the type 1 interferon (IFN) response; thus, HMGB2 led to the immune evasion of NSCLC. The gene discussed is HMGB2; the disease is non-small cell lung carcinoma.