CTLA4 and hepatocellular carcinoma: The objectives of the current research include the prediction of pathogenicity of IL-4 -590 C/T (rs2243250) and CTLA-4 + 49 A/G (rs231775) and the study of association between IL-4 -590 C/T (rs2243250) and CTLA-4 + 49 A/G (rs231775) polymorphisms with HCV-induced HCC.