To determine the prognostic factors in LEN-treated patients, a subgroup analysis was performed based on age (≥ or < 75 years), AFP level (≥ or < 400 ng/mL), tumor diameter (≥ or < 50 mm), liver tumor number (≥ or < 10), and Child–Pugh score (5 or 6). The gene discussed is AFP; the disease is neoplasm.