ANKRD26 and cancer: Meanwhile, 8 cancer predisposition gene mutations which were assessed as VUS were detected in 4 patients: ANKRD26 (NM_014915.2:c.3086A > T, p.(E1028V)), BARD1 (NM_000465.2:c.1862 T > C, p.(M151T)), DHX34 (NM_014681.5:c.1831G > A, p.(A611T)), ERCC6 (NM_000124.2:c.2996A > G, p.(A2996G)), FH (NM_000143.3:c.1434T > A, p.(N478K)), KDM1A (NM_001009999.2:c.44C > T, p.(A15V)), MST1R (NM_002447.2:c.1729delC, p.(H577fs)) and SMARCA4 (NM_001128849.1:c.4925A > C, p.(K1580T)) (Table 1 and Supplementary Table S1).