Other clinical and histologic features such as the age when low ANC was discovered, family history of cancer or recurrent infections, fever pattern, G-CSF responsiveness, organomegaly, extra-hematopoietic features, initial ANC level, M:E ratio, BM cellularity, MPO-positive cells, MPO grade and myelokathexis were not significantly different. The gene discussed is CSF3; the disease is infection.