ELANE and cyclic hematopoiesis: For example, ELANE p.(F43L), p.(A61V), p.(V101M), p.(S126L), p.(S126W), p.(P139L), p.(Q194X), IVS4 + 1G > A, IVS4 + 5G > A, p.(G214X), p.(R220Q) and p.(Y228X) can manifest as CN that can develop into MDS or AML, while they can also result in cyclic neutropenia with a relatively good prognosis25.