This study extended our earlier observation that neuroblastoma cells did not express PD-L1 whereas PD-L1 expression was detected on TAMs in the tumor tissues collected at diagnosis [5], and in fact, high PD-L1 expression on macrophages was associated with better patients survival as a whole and of the high-risk neuroblastoma, but not the low-risk subset (Fig. 3). Here, CD274 is linked to neuroblastoma.